Avandaryl and Myocardial infarction
Result of checking the interaction of drug Avandaryl and disease Myocardial infarction for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Safety data from a pooled analysis of 42 randomized, controlled clinical studies suggest that patients treated with rosiglitazone may have an increased risk of myocardial infarction and/or death from heart-related causes. The overall incidence of myocardial ischemia was 1.99% in patients receiving rosiglitazone-containing therapies (n = 8,604) for at least 24 weeks, compared to 1.51% in patients receiving placebo or other antidiabetic therapies (n = 5,633) for a similar duration. The hazard ratio was 1.31 (95% CI, 1.01 to 1.70) for rosiglitazone-treated patients relative to the comparators, which represents a greater than 30% excess risk of myocardial ischemic events in the rosiglitazone group. However, other published and unpublished data from long-term clinical trials of rosiglitazone provide contradictory evidence about the potential risks. Until more data are available, caution may be advisable when rosiglitazone is prescribed to patients with underlying heart disease or a history of myocardial infarction.
- Nissen SE, Wolski K "Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes." N Engl J Med 356 (2007): 2457-71
- FDA. United States Food and Drug Administration "Rosiglitazone maleate (marketed as Avandia, Avandamet, and Avandaryl) Available from: URL: http://www.fda.gov/cder/drug/InfoSheets/HCP/rosiglitazoneHCP.pdf." ([2007 Jun]):
Generic Name: glimepiride / rosiglitazone
Brand Name: Avandaryl
Synonyms: n.a.
Avandaryl - zawał mięśnia sercowego 
Avandaryl - infarto do miocárdio 
Avandaryl - infarksi miokardium 
Avandaryl - infark miokard 
Avandaryl - infarto miocardico 
Avandaryl - infarctus du myocarde 
Avandaryl - Herzinfarkt 
Avandaryl - infarto de miocardio 
Avandaryl - инфаркт миокарда 
Avandaryl - miyokardiyal enfarktüs 
Avandaryl - احتشاء عضلة القلب 
Avandaryl - 心肌梗塞