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Timoptic in Ocudose and Diabetes

Result of checking the interaction of drug Timoptic in Ocudose and disease Diabetes for safety when used together.

Check result:

Timoptic in Ocudose <> Diabetes

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Beta-adrenergic receptor blocking agents (aka beta-blockers) may mask symptoms of hypoglycemia such as tremors, tachycardia and blood pressure changes. In addition, the nonselective beta-blockers (e.g., timolol, carteolol) may inhibit catecholamine-mediated glycogenolysis, thereby potentiating insulin-induced hypoglycemia and delaying the recovery of normal blood glucose levels. Since topically applied beta-blockers are systemically absorbed and may produce clinically significant systemic effects even at low or undetectable plasma levels, therapy with ophthalmic beta-blockers should be administered cautiously in patients with diabetes or predisposed to spontaneous hypoglycemia.

References:

"Product Information. Betoptic (betaxolol ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.
"Product Information. Betaxon (levobetaxolol ophthalmic)" Alza, Palo Alto, CA.
"Product Information. Timoptic (timolol ophthalmic)." Merck & Co, Inc, West Point, PA.
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"Product Information. Ocupress (carteolol ophthalmic)" Ciba Vision Ophthalmics, Duluth, GA.
Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255
"Product Information. Betagan Liquifilm (levobunolol)." Allergan Inc, Irvine, CA.
"Product Information. OptiPranolol (metipranolol)." Bausch and Lomb, Tampa, FL.
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Grimaldi A, Bennett P, Delas B, et al "Beta-blockers and hypoglycaemia: assessment of cardioselective and intrinsic sympathomimetic properties in relation to severity of hypoglycaemia." Curr Ther Res Clin Exp 36 (1984): 361-73