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Timoptic in Ocudose and Cardiogenic shock

Result of checking the interaction of drug Timoptic in Ocudose and disease Cardiogenic shock for safety when used together.

Check result:

Timoptic in Ocudose <> Cardiogenic shock

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of ophthalmic beta-adrenergic receptor blocking agents (aka beta-blockers) is considered by manufacturers to be contraindicated in patients with cardiogenic shock. Topically applied beta-blockers are systemically absorbed, with the potential for producing clinically significant systemic effects even at low or undetectable plasma levels. In cardiac tissues, beta blockade causes a reduction in inotropic as well as chronotropic activity, which may further depress cardiac output and blood pressure in such patients.

References:

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"Product Information. Betoptic (betaxolol ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.
"Product Information. Timoptic (timolol ophthalmic)." Merck & Co, Inc, West Point, PA.
"Product Information. OptiPranolol (metipranolol)." Bausch and Lomb, Tampa, FL.
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"Product Information. Betagan Liquifilm (levobunolol)." Allergan Inc, Irvine, CA.
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"Product Information. Betaxon (levobetaxolol ophthalmic)" Alza, Palo Alto, CA.
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"Product Information. Ocupress (carteolol ophthalmic)" Ciba Vision Ophthalmics, Duluth, GA.