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Timoptic in Ocudose and Bradycardia/AV block

Result of checking the interaction of drug Timoptic in Ocudose and disease Bradycardia/AV block for safety when used together.

Check result:

Timoptic in Ocudose <> Bradycardia/AV block

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of ophthalmic beta-adrenergic receptor blocking agents (aka beta-blockers) is considered by manufacturers to be contraindicated in patients with sinus bradyarrhythmia or heart block greater than the first degree (unless a functioning pacemaker is present). Topically applied beta-blockers are systemically absorbed, with the potential for producing clinically significant systemic effects even at low or undetectable plasma levels. In cardiac tissues, beta blockade causes a reduction in inotropic as well as chronotropic activity, which may further depress cardiac function in such patients.

References:

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"Product Information. OptiPranolol (metipranolol)." Bausch and Lomb, Tampa, FL.
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"Product Information. Betaxon (levobetaxolol ophthalmic)" Alza, Palo Alto, CA.
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"Product Information. Timoptic (timolol ophthalmic)." Merck & Co, Inc, West Point, PA.
Mashford ML, Coventry D, Hecker R, et al. "Adverse Drug Reactions Advisory Committee: ADRAC report for 1980." Med J Aust 1 (1982): 416-9
"Product Information. Betoptic (betaxolol ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.
"Product Information. Ocupress (carteolol ophthalmic)" Ciba Vision Ophthalmics, Duluth, GA.