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Timolide and Renal/liver disease

Result of checking the interaction of drug Timolide and disease Renal/liver disease for safety when used together.

Check result:

Timolide <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Timolol is partially metabolized by the liver, and both parent drug and metabolites are eliminated by the kidney. Patients with renal and/or liver disease may be at greater risk for adverse effects from timolol due to decreased drug clearance. Therapy with timolol should be administered cautiously in patients with renal and/or liver dysfunction. Dosage adjustments may be necessary.

References:

"Product Information. Blocadren (timolol)." Merck & Co, Inc, West Point, PA.
McGourty JC, Silas JH, Fleming JJ, McBurney A, Ward JW "Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin." Clin Pharmacol Ther 38 (1985): 409-13
Lowenthal DT, Pitone JM, Affrime MB, et al "Timolol kinetics in chronic renal insufficiency." Clin Pharmacol Ther 23 (1978): 606-15
Dunn FG, Frohlich ED "Pharmacokinetics, mechanisms of action, indications, and adverse effects of timolol maleate, a nonselective beta-adrenoreceptor blocking agent." Pharmacotherapy 1 (1981): 188-200

Timolide

Generic Name: hydrochlorothiazide / timolol

Brand Name:

Synonyms: Timolide (Oral)

What is Timolide?