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Ticlopidine and Renal dysfunction

Result of checking the interaction of drug Ticlopidine and disease Renal dysfunction for safety when used together.

Check result:

Ticlopidine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ticlopidine is primarily eliminated by the kidney, and there is limited experience in patients with renal impairment. Elevated serum concentration of ticlopidine and prolonged half-live have been noted in patients with mild and moderate renal impairment. Prolonged bleeding times have been reported in patients with moderate renal impairment. Therapy with ticlopidine should be administered cautiously in patients with compromised renal function and dosage modifications may be necessary.

References:

"Product Information. Ticlid (ticlopidine)." Syntex Laboratories Inc, Palo Alto, CA.
Shah J, Teitelbaum P, Molony B, Gabuzda T, Massey I "Single and multiple dose pharmacokinetics of ticlopidine in young and elderly subjects." Br J Clin Pharmacol 32 (1991): 761-4

Ticlopidine

Generic Name: ticlopidine

Brand Name: Ticlid

Synonyms: n.a.

What is Ticlopidine?