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Ticlopidine and Hepatic dysfunction

Result of checking the interaction of drug Ticlopidine and disease Hepatic dysfunction for safety when used together.

Check result:

Ticlopidine <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of ticlopidine is contraindicated in patients with severe hepatic impairment. Ticlopidine is extensively metabolized to inactive forms by the liver. Therapy with ticlopidine should be administered cautiously in patients with mild to moderate hepatic impairment and dosage modifications should be considered. Clinical monitoring of hepatic function and bleeding activity is recommended.

References:

Saltiel E, Ward A "Ticlopidine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states." Drugs 34 (1987): 222-62
"Product Information. Ticlid (ticlopidine)." Syntex Laboratories Inc, Palo Alto, CA.
Picard-Fraire C "Pharmacokinetic and metabolic characteristics of ticlopidine in relation to its inhibitory properties on platelet function." Agents Actions Suppl 15 (1984): 68-75
Cassidy LJ, Schuster BG, Halparin LS "Probable ticlopidine-induced cholestatic hepatitis." Ann Pharmacother 29 (1995): 30-2

Ticlopidine

Generic Name: ticlopidine

Brand Name: Ticlid

Synonyms: n.a.

What is Ticlopidine?