Drug search by name

Thiothixene and Hematologic toxicity

Result of checking the interaction of drug Thiothixene and disease Hematologic toxicity for safety when used together.

Check result:

Thiothixene <> Hematologic toxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of phenothiazines has been associated with hematologic toxicity, including agranulocytosis, thrombocytopenia, eosinophilia, aplastic anemia, purpura, granulocytopenia, and hemolytic anemia. Mild leukopenia has occurred frequently with large doses over prolonged periods but has generally been reversible despite continued treatment. Since thiothixene is structurally related to the piperazine phenothiazines, the manufacturers recommend that it not be used in patients with preexisting blood dyscrasias. Leukopenia and leukocytosis, which are usually transient, have been reported with the use of thiothixene.

References:

Holt RJ "Fluphenazine decanoate-induced cholestatic jaundice and thrombocytopenia." Pharmacotherapy 4 (1984): 227-9
Aram H "Henoch-Schonlein purpura induced by chlorpromazine." J Am Acad Dermatol 17 (1987): 139-40
Young A, Kehoe R "Two cases of agranulocytosis on addition of a butyrophenone to a long-standing course of phenothiazine treatment." Br J Psychiatry 154 (1989): 710-12
"Product Information. Navane (thiothixene)." Roerig Division, New York, NY.
Balon R, Berchou R, Zethelius M "Thrombocytopenia associated with chlorpromazine, haloperidol and thiothixene: a case report." Can J Psychiatry 32 (1987): 149-50
Yassa R "Agranulocytosis in the course of phenothiazine therapy." J Clin Psychiatry 46 (1985): 341-3
Rosenthal DS, Stein GF, Santos JC "Thioridazine agranulocytosis." JAMA 200 (1967): 81-2
Stein P, Inwood M "Hemolytic anemia associated with chlorpromazine therapy." Can J Psychiatry 25 (1980): 659-61
Zengotita H, Holt R "Neuroleptic drug-induced coagulopathy: mechanism of reaction and duration of effect." J Clin Psychiatry 47 (1986): 35-7
Ben-Yehuda A, Bloom A, Lijhovetzky G, et al "Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis." Isr J Med Sci 26 (1990): 449-51
Holt R "Neuroleptic drug-induced changes in platelet levels." J Clin Psychopharmacol 4 (1984): 130-2