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Acetaminophen, magnesium salicylate, and pamabrom and Reye's syndrome

Result of checking the interaction of drug Acetaminophen, magnesium salicylate, and pamabrom and disease Reye's syndrome for safety when used together.

Check result:
Acetaminophen, magnesium salicylate, and pamabrom <> Reye's syndrome
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of salicylates, primarily aspirin, in children with varicella infections or influenza-like illnesses has been associated with an increased risk of Reye's syndrome. Although a causal relationship has not been established, the majority of evidence to date seems to support the association. Most authorities, including the American Academy of Pediatrics Committee on Infectious Diseases, recommend avoiding the use of salicylates in children and teenagers with known or suspected varicella or influenza and during presumed outbreaks of influenza. If antipyretic or analgesic therapy is indicated under these circumstances, acetaminophen may be an appropriate alternative. The same precautions should also be observed with related agents such as salicylamide or diflunisal because of their structural and pharmacological similarities to salicylate.

References:
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  • Epidemiology Office, Divisiion of Viral and Rickettsial Diseasses, Center for Infectious Diseases, Centers for Disease Control. "Leads from the MMWR. Reye syndrome surveillance--United States, 1987 and 1988." JAMA 261 (1989): 3520,
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Acetaminophen, magnesium salicylate, and pamabrom

Generic Name: acetaminophen / magnesium salicylate / pamabrom

Brand Name: Pamprin Cramp Formula

Synonyms: n.a.