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Tepadina Injection and Renal dysfunction

Result of checking the interaction of drug Tepadina Injection and disease Renal dysfunction for safety when used together.

Check result:

Tepadina Injection <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Approximately 25% of thiotepa is eliminated by the kidney and <2% is eliminated unchanged in the urine. The pharmacokinetic disposition of thiotepa has not be evaluated in patients with renal dysfunction. The use of thiotepa may be contraindicated in patients with existing renal dysfunction. If the need outweighs the risk, extreme caution should be exercised in administering thiotepa and therapy should be initiated at a reduced dosage. Clinical monitoring of renal function is recommended.

References:

Schellhammer PF "Renal failure associated with the use of thio-tepa." J Urol 110 (1973): 498-501
"Product Information. Thiotepa (thiotepa)." Hikma USA (formerly West-Ward Pharmaceutical Corporation), Eatontown, NJ.

Tepadina Injection

Generic Name: thiotepa

Brand Name: Tepadina, Thioplex

Synonyms: Tepadina

What is Tepadina Injection?