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Tacrolimus Oral, Intravenous and Hepatic dysfunction

Result of checking the interaction of drug Tacrolimus Oral, Intravenous and disease Hepatic dysfunction for safety when used together.

Check result:

Tacrolimus Oral, Intravenous <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tacrolimus undergoes significant hepatic metabolism, primarily by CYP450 3A enzymes. Less than 5% of tacrolimus is eliminated unchanged in the bile and <1% is eliminated unchanged in the urine. Moderate or severe hepatic dysfunction or impaired post-transplant hepatic function may alter the metabolic and therapeutic activity of tacrolimus and increase the whole blood tacrolimus concentration. Therapy with tacrolimus should be administered cautiously and dosage adjustments considered in the presence of moderate or severe hepatic impairment.

References:

Mekki Q, Lee C, Aweeka F, et al. "Pharmacokinetics of tacrolimus (FL506) in kidney transplant patients." Clin Pharmacol Ther 53 (1993): 238
"Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.

Tacrolimus Oral, Intravenous

Generic Name: tacrolimus

Brand Name: Astagraf XL, Envarsus XR, Prograf, Hecoria

Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)

What is Tacrolimus Oral, Intravenous?