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Sotalol Intravenous and Renal dysfunction

Result of checking the interaction of drug Sotalol Intravenous and disease Renal dysfunction for safety when used together.

Check result:

Sotalol Intravenous <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Sotalol is primarily eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from sotalol, including torsade de pointes and worsened ventricular tachycardia, due to decreased drug clearance. Therapy with sotalol should be administered cautiously in patients with renal impairment. Dosage adjustments (i.e. prolongation of dosing interval) are recommended in patients with moderate to severe renal dysfunction (CrCl <= 60 mL/min), and dosage escalations should occur not more often than after administration of every 5 to 6 doses. Heart rate and ECG, particularly the QTc interval, should be closely monitored.

References:

Blair AD, Burgess ED, Maxwell BM, Cutler RE "Sotalol kinetics in renal insufficiency." Clin Pharmacol Ther 29 (1981): 457-63
Dumas M, d'Athis P, Besancenot JF, Chadoint-Noudeau V, Chalopin JM, Rifle G, Escousse A "Variations of sotalol kinetics in renal insufficiency." Int J Clin Pharmacol Ther Toxicol 27 (1989): 486-9
"Product Information. Betapace (sotalol)." Berlex, Richmond, CA.
Berglund G, Descamps R, Thomis JA "Pharmacokinetics of sotalol after chronic administration to patients with renal insufficiency." Eur J Clin Pharmacol 18 (1980): 321-6
Tjandramaga TB, Verbeeck R, Thomas J, Verbesselt R, Verberckmoes R, Schepper PJD "The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol." Br J Clin Pharmacol 3 (1976): 259-65
Tjandramaga TB, Verbeeck R, Verbesselt R, Verberckmoes R, De Schepper PJ. Influence of chronic renal failure and haemodialysis on the elimination of the beta-adrenoceptor blocking drugs practolol and sotalol. In: Saxena PR, Forsyth R P, eds. "Beta-adrenoceptor Blocking Agents." Amsterdam, North-Holland, : (1976): 323-33
Patrick GM, Pollock CA, Ibels LS, Caterson RJ "Sotalol and end-stage renal failure." Aust N Z J Med 24 (1994): 319-20

Sotalol Intravenous

Generic Name: sotalol

Brand Name: Betapace, Sorine, Betapace AF, Sotalol Hydrochloride AF, Sotylize

Synonyms: Sotalol (Intravenous)

What is Sotalol Intravenous?