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Sotalol Intravenous and QT interval prolongation

Result of checking the interaction of drug Sotalol Intravenous and disease QT interval prolongation for safety when used together.

Check result:

Sotalol Intravenous <> QT interval prolongation

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of sotalol is contraindicated in patients with congenital or acquired QT interval prolongation syndromes. Sotalol has dose-dependent proarrhythmic effects related to prolongation of the QT interval. The risk of torsades de pointes is progressively increased as the degree of prolongation becomes greater. The manufacturer states that sotalol should be used with particular caution in patients whose QTc is greater than 500 msec on- therapy. Serious consideration should be given to reducing the dosage or discontinuing therapy when the QTc exceeds 550 msec.

The use of sotalol is contraindicated in patients with hypokalemia (< 4 meq/L). Electrolyte disturbances such as hypokalemia and hypomagnesemia may augment the prolongation effect of sotalol on the QT interval and should be corrected prior to institution of sotalol therapy. In addition, patients who experience frequent, severe, or prolonged diarrhea may be subject to electrolyte losses and should be followed closely and managed accordingly during therapy with sotalol.

References:

Allberry RA "Torsade de pointes." Anaesthesia 38 (1983): 910
Arstall MA, Hii JT, Lehman RG, Horowitz JD "Sotalol-induced torsade de pointes: management with magnesium infusion." Postgrad Med J 68 (1992): 289-90
Krapf R, Gertsch M "Torsade de pointes induced by sotalol despite therapeutic plasma sotalol concentrations." Br Med J (Clin Res Ed) 290 (1985): 1784-5
McKibbin JK, Pocock WA, Barlow JB, Millar RN, Obel IW "Sotalol, hypokalaemia, syncope, and torsade de pointes." Br Heart J 51 (1984): 157-62
"Product Information. Betapace (sotalol)." Berlex, Richmond, CA.
Laakso M, Pentikainen PJ, Rehnberg S "Sotalol-induced prolongation of the Q-T interval and attacks of unconsciousness." Int J Clin Pharmacol Ther Toxicol 22 (1984): 487-90
Neuvonen PJ, Elonen E, Tanskanen A, Tuomilehto J "Sotalol prolongation of the QTc interval in hypertensive patients." Clin Pharmacol Ther 32 (1982): 25-32
Suttorp MJ, Kingma JH, Tjon Joe Gin RM, van Hemel NM, Koomen EM, Defauw JA, Adan AJ, Ernst SM "Efficacy and safety of low- and high-dose sotalol versus propranolol in the prevention of supraventricular tachyarrhythmias early after coronary artery bypass operations." J Thorac Cardiovasc Surg 100 (1990): 921-6
Soyka LF, Wirtz C, Spangenberg RB "Clinical safety profile of sotalol in patients with arrhythmias." Am J Cardiol 65 (1990): a74-81;
Antonaccio MJ, Lessem JN, Soyka LF "Sotalol, hypokalaemia, syncope, and torsade de pointes." Br Heart J 52 (1984): 358-9
Gossinger HD, Siostrzonek P, Schmoliner R, Grimm G, Jager U, Mosslacher H "Sotalol-induced torsades de pointes in a patient with pre-existent normal response to programmed ventricular stimulation." Eur Heart J 8 (1987): 1351-3
Hohnloser SH, Zabel M, van de Loo A, Klingenheben T, Just H "Efficacy and safety of sotalol in patients with complex ventricular arrhythmias." Int J Cardiol 37 (1992): 283-91
Rakovec P, Cercek B, Rode P, Brucan A, Horvat M "Sotalol-induced torsade de pointes." Cathet Cardiovasc Diagn 10 (1984): 167-70
Kuck KH, Kunze KP, Roewer N, Bleifeld W "Sotalol-induced torsade de pointes." Am Heart J 107 (1984): 179-80
Jordaens L, Gorgels A, Stroobandt R, Temmerman J "Efficacy and safety of intravenous sotalol for termination of paroxysmal supraventricular tachycardia. The Sotalol Versus Placebo Multicenter Study Group." Am J Cardiol 68 (1991): 35-40
Cui GG, Sen LY, Sager P, Uppal P, Singh BN "Effects of amiodarone, sematilide, and sotalol on QT dispersion." Am J Cardiol 74 (1994): 896-900
Lehmann MH, Hardy S, Archibald D, Quart B, Macneil DJ "Sex difference in risk of torsade de pointes with d,l-sotalol." Circulation 94 (1996): 2535-41
Griffith MJ, Linker NJ, Garratt CJ, Ward DE, Camm AJ "Relative efficacy and safety of intravenous drugs for termination of sustained ventricular tachycardia." Lancet 336 (1990): 670-3