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Sotalol Intravenous and Hemodialysis

Result of checking the interaction of drug Sotalol Intravenous and disease Hemodialysis for safety when used together.

Check result:

Sotalol Intravenous <> Hemodialysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Therapy with sotalol should be administered cautiously in patients with renal failure undergoing hemodialysis. The half-life of sotalol is prolonged (up to 69 hours) in anuric patients. Although sotalol is partially removed by hemodialysis, a rebound in drug concentration often occurs after dialysis is complete. Sotalol should preferably be administered after dialysis and after hemodynamic stability has been established. Heart rate and ECG, particularly the QTc interval, must be closely monitored.

References:

Tjandramaga TB, Verbeeck R, Verbesselt R, Verberckmoes R, De Schepper PJ. Influence of chronic renal failure and haemodialysis on the elimination of the beta-adrenoceptor blocking drugs practolol and sotalol. In: Saxena PR, Forsyth R P, eds. "Beta-adrenoceptor Blocking Agents." Amsterdam, North-Holland, : (1976): 323-33
Singh SN, Lazin A, Cohen A, Johnson M, Fletcher RD "Sotalol-induced torsades de pointes successfully treated with hemodialysis after failure of conventional therapy." Am Heart J 121 (1991): 601-2
Tjandramaga TB, Verbeeck R, Thomas J, Verbesselt R, Verberckmoes R, Schepper PJD "The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol." Br J Clin Pharmacol 3 (1976): 259-65
"Product Information. Betapace (sotalol)." Berlex, Richmond, CA.

Sotalol Intravenous

Generic Name: sotalol

Brand Name: Betapace, Sorine, Betapace AF, Sotalol Hydrochloride AF, Sotylize

Synonyms: Sotalol (Intravenous)

What is Sotalol Intravenous?