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Astagraf XL and Renal dysfunction

Result of checking the interaction of drug Astagraf XL and disease Renal dysfunction for safety when used together.

Check result:

Astagraf XL <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nephrotoxicity has been reported in 52% of kidney and 40% of liver transplant patients. Renal toxicity includes increasing serum creatinine and blood urea nitrogen, and renal failure sometimes requiring hemodialysis. Oliguria and hematuria also have been reported. The mechanism of tacrolimus-induced renal dysfunction is not well established. Renal toxicity appears to be dose-related, although toxicity may still occur even at suggested therapeutic concentrations. Therapy with tacrolimus should be administered cautiously and dosage reductions may be necessary in patients with compromised renal function. Alternative immunosuppressive therapy should be considered in the presence of persistent or worsening renal dysfunction.

References:

McCauley J, Takaya S, Fung J, et al "The question of FK 506 nephrotoxicity after liver transplantation." Transplant Proc 23 (1991): 1444-7
Platz KP, Mueller AR, Blumhardt G, Bachmann S, Bechstein WO, Kahl A, Neuhaus P "Nephrotoxicity following orthotopic liver transplantation - a comparison between cyclosporine and FK506." Transplantation 58 (1994): 170-8
Fries D, Rucay P, Samuel D, Hiesse C, Meduri G, Callard P, Fredj G, Bismuth H "Development of renal dysfunction and renal histological lesions in two patients treated with FK 506 for acute rejection following liver transplantation." Transplant Proc 23 (1991): 3099-100
Porayko MK, Textor SC, Krom RA, Hay JE, Gores GJ, Richards TM, Crotty PH, Beaver SJ, Steers JL, Wiesner RH "Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation." Mayo Clin Proc 69 (1994): 105-11
Winkler M, Jost U, Ringe B, Gubernatis G, Wonigeit K, Pichlmayr R "Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients." Transplant Proc 23 (1991): 3153-5
Sumpio BE, Phan S "Nephrotoxic potential of FK 506." Transplant Proc 23 (1991): 2789-90
"Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.

Astagraf XL

Generic Name: tacrolimus

Brand Name: Astagraf XL, Envarsus XR, Prograf, Hecoria

Synonyms: n.a.

What is Astagraf XL?