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Astagraf XL and Diabetes mellitus

Result of checking the interaction of drug Astagraf XL and disease Diabetes mellitus for safety when used together.

Check result:

Astagraf XL <> Diabetes mellitus

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tacrolimus can induce post-transplant insulin-dependent diabetes mellitus (PTDM). Temporary insulin therapy has been required in some patients, while long-term insulin use has been necessary in others. Reversible insulin dependence has occurred in kidney and liver transplant patients. PTDM has occurred in a greater percentage of tacrolimus-treated (20%) versus cyclosporine-treated (4%) kidney transplant patients. Black and Hispanic patients are at increased risk for PTDM. Therapy with tacrolimus should be administered cautiously in patients with pre-transplant diabetes mellitus.

References:

Tabasco-Minguillan J, Mieles L, Carroll P, Gavaler J, Van Thiel DH, Starzl TE "Long-term insulin requirement after liver transplantation with FK 506 in American veterans." Transplant Proc 25 (1993): 677-8
"Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
Carroll PB, Rilo H, Reyes J, Alejandro R, Zeng Y, Ricordi C, Tzakis A, Shapiro R, Starzl TE "Fk 506-associated diabetes mellitus in the pediatric transplant population is a rare complication." Transplant Proc 23 (1991): 3171-2
Scantlebury V, Shapiro R, Fung J, Tzakis A, McCauley J, Jordan M, Jensen C, Hakala T, Simmons R, Starzl TE "New onset of diabetes in FK 506 vs cyclosporine-treated kidney transplant recipients." Transplant Proc 23 (1991): 3169-70
Odocha O, McCauley J, Scantlebury V, Shapiro R, Carroll P, Jordan M, Vivas C, Fung JJ, Starzl TE "Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression." Transplant Proc 25 (1993): 2433-4

Astagraf XL

Generic Name: tacrolimus

Brand Name: Astagraf XL, Envarsus XR, Prograf, Hecoria

Synonyms: n.a.

What is Astagraf XL?