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Sinequan (Doxepin Oral Concentrate) and Seizure disorders

Result of checking the interaction of drug Sinequan (Doxepin Oral Concentrate) and disease Seizure disorders for safety when used together.

Check result:

Sinequan (Doxepin Oral Concentrate) <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tricyclic antidepressants (TCAs), can lower the seizure threshold and trigger seizures. These drugs should be used with extreme caution in patients with a history of seizures, or other predisposing factors, such as head trauma, CNS abnormalities, and alcoholism. Daily dose restrictions might apply for specific antidepressants. Physicians are encouraged to get additional dosing recommendations on the manufacturer's prescribing information.

References:

Pascual J, Combarros O, Berciano J "Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment." Clin Neuropharmacol 10 (1987): 565-7
"Product Information. Anafranil (clomipramine)." Basel Pharmaceuticals, Summit, NJ.
Robinson ML "Epileptic fit after clomipramine." Br J Psychiatry 132 (1978): 525-6
Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30
Flechter S, Rabey JM, Regev I, Borenstein N, Vardi J "Convulsive attacks due to antidepressant drug overdoses: case reports and discussion." Gen Hosp Psychiatry 5 (1983): 217-21

Sinequan (Doxepin Oral Concentrate)

Generic Name: doxepin

Brand Name: Sinequan, Sinequan, Silenor

Synonyms: Sinequan Capsules, Sinequan

What is Sinequan (Doxepin Oral Concentrate)?