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Seconal and Liver disease

Result of checking the interaction of drug Seconal and disease Liver disease for safety when used together.

Check result:

Seconal <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Barbiturates are extensively metabolized by the liver. The plasma clearance of barbiturates may be decreased and the half-lives prolonged in patients with impaired hepatic function. Therapy with barbiturates should be administered cautiously and initiated at reduced dosages in patients with liver disease. Barbiturates are not recommended for use in patients with cirrhosis, hepatic failure, hepatic coma, or other severe hepatic impairment.

References:

"Product Information. Phenobarbital (phenobarbital)." Lilly, Eli and Company, Indianapolis, IN.
Kallberg N, Agurell S, Ericsson O, et al "Quantitation of phenobarbital and its main metabolites in human urine." Eur J Clin Pharmacol 9 (1975): 161-8
"Product Information. Amytal Sodium (amobarbital)" Lilly, Eli and Company, Indianapolis, IN.
Whyte MP, Dekaban "Metabolic fate of phenobarbital: a quantitative study of p-hydroxyphenobarbital elimination in man." Drug Metab Dispos 5 (1977): 63-9
"Product Information. Mebaral (mephobarbital)" Sanofi Winthrop Pharmaceuticals, New York, NY.
"Product Information. Butisol Sodium (butabarbital)" Wallace Laboratories, Cranbury, NJ.
"Product Information. Nembutal Sodium (pentobarbital)" Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Seconal Sodium (secobarbital)" Lilly, Eli and Company, Indianapolis, IN.
Alvin J, McHorse T, Hoyumpa A, et al "The effect of liver disease in man on the disposition of phenobarbital." J Pharmacol Exp Ther 192 (1975): 224-35

Seconal

Generic Name: secobarbital

Brand Name: Seconal, Seconal Sodium

Synonyms: n.a.

What is Seconal?