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Seconal and Adrenal insufficiency

Result of checking the interaction of drug Seconal and disease Adrenal insufficiency for safety when used together.

Check result:

Seconal <> Adrenal insufficiency

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Barbiturates, especially phenobarbital, secobarbital and butabarbital, may diminish the systemic effects of exogenous and endogenous corticosteroids via induction of hepatic microsomal enzymes, thereby accelerating the metabolism of corticosteroids. In addition, barbiturates may interfere with pituitary corticotropin production. Therapy with barbiturates should be administered cautiously in patients with adrenal insufficiency. Patients with borderline hypoadrenalism should be monitored closely, and patients receiving steroid supplementation may require an adjustment in dosage when barbiturates are added to or withdrawn from their medication regimen.

References:

"Product Information. Seconal Sodium (secobarbital)" Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Nembutal Sodium (pentobarbital)" Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Butisol Sodium (butabarbital)" Wallace Laboratories, Cranbury, NJ.
"Product Information. Amytal Sodium (amobarbital)" Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Phenobarbital (phenobarbital)." Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Mebaral (mephobarbital)" Sanofi Winthrop Pharmaceuticals, New York, NY.

Seconal

Generic Name: secobarbital

Brand Name: Seconal, Seconal Sodium

Synonyms: n.a.

What is Seconal?