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Saxagliptin and Metformin and Renal dysfunction

Result of checking the interaction of drug Saxagliptin and Metformin and disease Renal dysfunction for safety when used together.

Check result:

Saxagliptin and Metformin <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

It is recommended to assess renal function prior to initiating treatment with DPP-4 inhibitors. Patients with moderate to severe renal insufficiency and end stage renal dysfunction will require a dose adjustment. Linagliptin will not require a dose adjustment per manufacturer's information. Additionally, there have been postmarketing reports of worsening renal function in some patients with renal insufficiency taking sitagliptin at inappropriate doses. However, sitagliptin has not been found to be nephrotoxic in preclinical studies or clinical trials at appropriate doses.

Saxagliptin and Metformin

Generic Name: metformin / saxagliptin

Brand Name: Kombiglyze XR

Synonyms: Metformin and saxagliptin

What is Saxagliptin and Metformin?