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Sandostatin LAR and Glucose intolerance

Result of checking the interaction of drug Sandostatin LAR and disease Glucose intolerance for safety when used together.

Check result:

Sandostatin LAR <> Glucose intolerance

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The incidence of hypoglycemia may increase during octreotide therapy due to inhibition of glucagon and growth hormone. Hyper- and hypoglycemia have been associated with the use of octreotide in nondiabetic patients with acromegaly. Clinical monitoring of blood glucose is recommended in patients with diabetes or insulinoma.

References:

Breidert M, Pinzer T, Wildbrett J, Bornstein SR, Hanefeld M "Long-term effect of octreotide in acromegaly on insulin resistance." Horm Metab Res 27 (1995): 226-30
McKnight JA, McCance DR, Crothers JG, Atkinson AB "Changes in glucose tolerance and development of gall stones during high dose treatment with octreotide for acromegaly." BMJ 299 (1989): 604-5
Osei K, O'Dorisio TM, Malarkey WB, Craig EL, Cataland S "Metabolic effects of long-acting somatostatin analogue (sandostatin) in type I diabetic patients on conventional therapy." Diabetes 38 (1989): 704-9
"Product Information. Sandostatin (octreotide)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Abrahamson MJ "Death from diabetic ketoacidosis after cessation of octreotide in acromegaly." Lancet 336 (1990): 318-9
Lamberts SWJ, Vanderlely AJ, Deherder WW, Hofland LJ "Octreotide exacerbated fasting hypoglycaemia in a patient with a proinsulinoma; the glucostatic importance of pancreatic glucagon - commentary." Clin Endocrinol (Oxf) 43 (1995): 120-2
Gama R, Marks V, Wright J, Teale JD "Octreotide exacerbated fasting hypoglycaemia in a patient with a proinsulinoma; the glucostatic importance of pancreatic glucagon." Clin Endocrinol (Oxf) 43 (1995): 117-20

Sandostatin LAR

Generic Name: octreotide

Brand Name: Sandostatin, Sandostatin LAR Depot

Synonyms: Octreotide (injection), Octreotide

What is Sandostatin LAR?