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Sandostatin LAR and Gallbladder/biliary dysfunction

Result of checking the interaction of drug Sandostatin LAR and disease Gallbladder/biliary dysfunction for safety when used together.

Check result:

Sandostatin LAR <> Gallbladder/biliary dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Octreotide inhibits gallbladder contractility and may alter bile composition. An average of 29% of patients develop new gallstones during octreotide therapy, and up to 20% of patients develop biliary sludge. Associated pancreatitis has been reported in rare cases. Gallbladder hypercontractility, sometimes resulting in biliary colic, has been reported upon withdrawal of octreotide.

References:

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Daughaday WH "Octreotide is effective in acromegaly but often results in cholelithiasis." Ann Intern Med 112 (1990): 159-60
Gradon JD, Schulman RH, Chapnick EK, Sepkowitz DV "Octreotide-induced acute pancreatitis in a patient with acquired immunodeficiency syndrome." South Med J 84 (1991): 1410-1
Dowling RH, Hussaini SH, Murphy GM, Wass JA "Gallstones during octreotide therapy." Digestion 55 Suppl 1 (1993): 107-20
Sadoul JL, Benchimol D, Thyss A, Freychet P "Side-effects of octreotide withdrawal." Lancet 339 (1992): 376
Catnach SM, Wass JA, Anderson JV, Besser M, Fairclough P, Hussaini H, Dowling H "Gall stones induced by octreotide." BMJ 305 (1992): 313
Fredenrich A, Sosset C, Bernard JL, Sadoul JL, Freychet P "Acute pancreatitis after short-term octreotide." Lancet 338 (1991): 52-3
Dowling RH, Hussaini SH, Murphy GM, Besser GM, Wass JA "Gallstones during octreotide therapy." Metabolism 41(9 Suppl) (1992): 22-33
Shi YF, Zhu XF, Harris AG, Zhang JX, Dai Q "Prospective study of the long-term effects of somatostatin analog (octreotide) on gallbladder function and gallstone formation in Chinese acromegalic patients." J Clin Endocrinol Metab 76 (1993): 32-7
Redfern JS, Fortuner WJ "Octreotide-associated biliary tract dysfunction and gallstone formation: pathophysiology and management." Am J Gastroenterol 90 (1995): 1042-52
"Product Information. Sandostatin (octreotide)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Baxter JN, Imrie CW, McKay CJ "Acute pancreatitis and octreotide." Lancet 338 (1991): 389
James RA, Rhodes M, Rose P, Kendall-Taylor P "Biliary colic on abrupt withdrawal of octreotide." Lancet 338 (1991): 1527
Ahrendt SA, McGuire GE, Pitt HA, Lillemoe KD "Why does somatostatin cause gallstones?" Am J Surg 161 (1991): 177-82;disc. 182-3