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Ryzolt and Respiratory depression

Generic Name: tramadol
Dosage Forms: tablet, extended release
Other Brand Names: ConZip , Rybix ODT , Ryzolt , Ultram , Ultram ER

Result of checking the interaction of drug Ryzolt and disease Respiratory depression for safety when used together.

Check result:

Ryzolt <> Respiratory depression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tramadol may produce some respiratory depression, but less than morphine at recommended dosages. Respiratory depression most often occurs when tramadol is given in high dosages with anesthetic medications or alcohol. Tramadol may also increase airway resistance, which can result in dyspnea. In general, the respiratory effects at therapeutic analgesic dosages are not clinically important except in some patients with preexisting pulmonary impairment. Therapy with tramadol should be administered cautiously in patients with underlying CNS and respiratory depression; sleep apnea; hypoxia, anoxia, or hypercapnia; upper airway obstruction; chronic pulmonary insufficiency; a limited ventilatory reserve; or other respiratory disorders. Caution is also advised in patients who may be at increased risk for respiratory depression, such as comatose patients or those with head injury, intracranial lesions, or intracranial hypertension. If clinically significant respiratory depression occurs, naloxone may be administered. However, it may only partially antagonize the effects of tramadol while increasing the risk of tramadol-associated seizures.

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