Drug search by name

Rybix ODT and Renal dysfunction

Generic Name: tramadol
Dosage Forms: tablet, orally disintegrating
Other Brand Names: ConZip , Ultram , Ultram ER , Rybix ODT , Ryzolt

Result of checking the interaction of drug Rybix ODT and disease Renal dysfunction for safety when used together.

Check result:

Rybix ODT <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tramadol and its metabolites, one of which (referred to as M1) is pharmacologically active and a more potent analgesic than tramadol itself, are primarily excreted in the urine. The rate and extent of excretion of both tramadol and M1 have been shown to decrease in patients with impaired renal function. Therapy with tramadol should be administered cautiously in such patients. The manufacturer recommends increasing the dosing interval to every 12 hours, with a maximum daily dosage of 200 mg, in patients with creatinine clearance below 30 mL/min.

References: