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Asendin and NMS

Result of checking the interaction of drug Asendin and disease NMS for safety when used together.

Check result:

Asendin <> NMS

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Although not a neuroleptic agent, amoxapine has substantive neuroleptic activity due to its dopaminergic receptor-blocking effects and may precipitate or aggravate a potentially fatal symptom complex known as Neuroleptic Malignant Syndrome (NMS). Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, involuntary movements, altered mental status and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias). Amoxapine therapy should not be initiated in patients with active NMS and should be immediately discontinued if currently being administered in such patients. In patients with a history of NMS, introduction or reintroduction of amoxapine therapy should be carefully considered, since NMS may recur.

References:

"Product Information. Asendin (amoxapine)" Lederle Laboratories, Wayne, NJ.
Baca L, Martinelli L "Neuroleptic malignant syndrome: a unique association with a tricyclic antidepressant." Neurology 40 (1990): 1797-8

Asendin

Generic Name: amoxapine

Brand Name: Asendin

Synonyms: Asendin (Oral)

What is Asendin?