Drug search by name

Risperdal M-Tab and QT interval prolongation

Result of checking the interaction of drug Risperdal M-Tab and disease QT interval prolongation for safety when used together.

Check result:

Risperdal M-Tab <> QT interval prolongation

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Risperidone and its active metabolite, 9-hydroxyrisperidone, can prolong the QT interval of the electrocardiogram in some patients. The risk of torsade de pointes is progressively increased as the degree of prolongation becomes greater. Therapy with risperidone should be administered cautiously, if at all, in patients with congenital or acquired QT interval prolongation syndromes. Electrolyte disturbances such as hypokalemia and hypomagnesemia may augment the prolongation effect of risperidone on the QT interval and should be corrected prior to institution of risperidone therapy. In addition, patients who experience frequent, severe, or prolonged diarrhea may be subject to electrolyte losses and should be followed closely and managed accordingly during therapy with risperidone.

References:

"Product Information. Risperdal (risperidone)." Janssen Pharmaceutica, Titusville, NJ.
Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82
Huang CL, Su KP, Hsu HB, Pariante CM "A pilot observational crossover study of QTc interval changes associated with switching between olanzapine and risperidone." J Clin Psychiatry 68 (2007): 803-5

Risperdal M-Tab

Generic Name: risperidone

Brand Name: Risperdal M-Tab, Perseris, Risperdal Consta, Risperdal, Risperdal Consta

Synonyms: n.a.

What is Risperdal M-Tab?