Rifater and Renal dysfunction
Result of checking the interaction of drug Rifater and disease Renal dysfunction for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:The half-life of pyrazinamide may be prolonged in patients with renal impairment. In addition, the drug's metabolites, at least one of which is pharmacologically active, may accumulate. Therapy with pyrazinamide should be administered cautiously in patients with renal dysfunction. Dosage adjustments may be necessary.
- Stamatakis G, Montes C, Trouvin JH, et al "Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure." Clin Nephrol 30 (1988): 230-4
- "Product Information. Pyrazinamide (pyrazinamide)." VersaPharm Inc, Marietta, GA.
- Ellard GA "Absorption, metabolism and excretion of pyrazinamide in man." Tubercle 50 (1969): 144-58
- Mandell GL, Bennett JE, Dolin R, eds.. "Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 4th ed." New York, NY: Churchill Livingston 1 (1995):
Generic Name: isoniazid / pyrazinamide / rifampin
Brand Name: Rifater
Synonyms: n.a.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Isoniazid is metabolized primarily by acetylation and dehydrazination in the liver. It is not significantly excreted by the kidney. Dosage adjustments in renal impairment are generally not necessary except in slow acetylators with a creatinine clearance below 10 mL/min. The rate of acetylation is genetically determined. Approximately 50% of blacks and caucasians are slow acetylators, and the majority of Eskimos and Asians are rapid acetylators.
- "Product Information. Nydrazid (isoniazid)" Apothecon Inc, Princeton, NJ.
- "Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
- Andrew OT, Schoenfeld PY, Hopewell PC, Humphreys MH "Tuberculosis in patients with end-stage renal disease." Am J Med 68 (1980): 59-65
- Bowerson DW, Winterbauer RH, Stewart GL, et al "Isoniazid dosage in patients with renal failure." N Engl J Med 289 (1973): 84-7
- Kim YG, Shin JG, Shin SG, Jang IJ, Kim SG, Lee JS, Han JS, Cha YN "Decreased acetylation of isoniazid in chronic renal failure." Clin Pharmacol Ther 54 (1993): 612-20
- Reidenberg MM, Shear L, Cohen RV "Elimination of isoniazid in patients with impaired renal function." Am Rev Respir Dis 108 (1973): 1426-8
- Gold CH, Buchanan N, Tringham V, et al "Isoniazid pharmacokinetics in patients with chronic renal failure." Clin Nephrol 6 (1976): 365-9
- Boxenbaum HG, Bekersky I, Mattaliano V, Kaplan SA "Plasma and salivary concentrations of isoniazid in man: preliminary findings in two slow acetylator subjects." J Pharmacokinet Biopharm 3 (1975): 443-56
- Mitchison DA, Ellard GA "Tuberculosis in patients having dialysis." Br Med J 280 (1980): 1533
Generic Name: isoniazid / pyrazinamide / rifampin
Brand Name: Rifater
Synonyms: n.a.
Rifater - Niewydolność nerek 
Rifater - disfunção renal 
Rifater - disfungsi buah pinggang 
Rifater - disfungsi ginjal 
Rifater - disfunzione renale 
Rifater - dysfonctionnement rénal 
Rifater - Nierenfunktionsstörung 
Rifater - disfuncion renal 
Rifater - почечная дисфункция 
Rifater - Böbrek yetmezliği 
Rifater - الفشل الكلوي 
Rifater - 肾功能不全