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Reserpine, hydralazine, and hydrochlorothiazide and Depression

Result of checking the interaction of drug Reserpine, hydralazine, and hydrochlorothiazide and disease Depression for safety when used together.

Check result:
Reserpine, hydralazine, and hydrochlorothiazide <> Depression
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of rauwolfia alkaloids is contraindicated in patients with a history of mental depression, especially suicidal tendencies. Rauwolfia alkaloids depletes catecholamine and serotonin stores.

References:
  • Goodwin FK, Bunney WE, Jr "Depressions following reserpine: a reevaluation." Semin Psychiatry 3 (1971): 435-48
  • Lewis WH "Iatrogenic psychotic depressive reaction in hypertensive patients." Am J Psychiatry 127 (1971): 1416-7
  • Ambrosino SV "Depressive reactions associated with reserpine." N Y State J Med 74 (1974): 860-4
  • Fleishman M "Letter: Reserpine, ECT, and depression." Am J Psychiatry 132 (1975): 1088
  • "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Reserpine, hydralazine, and hydrochlorothiazide

Generic Name: hydralazine / hydrochlorothiazide / reserpine

Brand Name:

Synonyms: Reserpine, hydralazine, and hydrochlorothiazide (Oral)