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Requip and Hepatic dysfunction

Result of checking the interaction of drug Requip and disease Hepatic dysfunction for safety when used together.

Check result:

Requip <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The pharmacokinetic disposition of ropinirole has not been studied in patients with hepatic impairment, however, the serum concentration of ropinirole may be increased and the elimination half-life prolonged in these patients. Therapy with ropinirole should be administered cautiously in patients with hepatic impairment, and dosages titrated according to patient parameters and clinical tolerability.

References:

"Product Information. Requip (ropinirole)." SmithKline Beecham, Philadelphia, PA.
Bloomer JC, Clarke SE, Chenery RJ "In vitro identification of the P450 enzymes responsible for the metabolism of ropinirole." Drug Metab Dispos 25 (1997): 840-4

Requip

Generic Name: ropinirole

Brand Name: Requip, Requip XL, ReQuip Follow on Pack, ReQuip Starter Pack, Repreve, Requip Starter Kit

Synonyms: n.a.

What is Requip?