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Reglan (Metoclopramide Injection Solution) and Renal dysfunction

Result of checking the interaction of drug Reglan (Metoclopramide Injection Solution) and disease Renal dysfunction for safety when used together.

Check result:

Reglan (Metoclopramide Injection Solution) <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Renal function affects the clearance of metoclopramide. In patients with varying degrees of renal impairment, a reduction in creatinine clearance was correlated with a reduction in plasma clearance, renal clearance, and non-renal clearance, and increase in elimination half-life of metoclopramide. Therapy with metoclopramide should be administered cautiously in patients with impaired renal function. A dosage reduction may be appropriate to avoid drug accumulation.

References:

Lloveras J, Masramon J, Aubia J, Llorach M "Amiodarone, metoclopramide, and renal failure." Lancet 1 (1979): 981-2
Bateman DN, Gokal R, Dodd TR, Blain PG "The pharmacokinetics of single doses of metoclopramide in renal failure." Eur J Clin Pharmacol 19 (1981): 437-41
Caralps A "Metoclopramide and renal failure." Lancet 1 (1979): 554
"Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Lehmann CR, Heironimus JD, Collins CB, O'Neil TJ, Pierson WP, Crowe JT, Melikian AP, Wright GJ "Metoclopramide kinetics in patients with impaired renal function and clearance by hemodialysis." Clin Pharmacol Ther 37 (1985): 284-9

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand Name: Reglan, Metozolv ODT

Synonyms: Reglan

What is Reglan (Metoclopramide Injection Solution)?