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Ranitidine and Renal dysfunction

Result of checking the interaction of drug Ranitidine and disease Renal dysfunction for safety when used together.

Check result:

Ranitidine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ranitidine is primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution.

References:

McFayden ML, Folb PI, Miller R, et al "Pharmacokinetics of ranitidine in patients with chronic renal failure." Eur J Clin Pharmacol 25 (1983): 347-51
Meffin PJ, Grgurinovich N, Brooks PM, et al "Ranitidine disposition in patients with renal impairment." Br J Clin Pharmacol 16 (1983): 731-4
Kopitar Z, Cvelbar P, Zorz M, et al "Pharmacokinetics of ranitidine in adult patients with end stage renal disease after single and multiple dosing." Acta Pharm Juglosl 37 (1987): 371-9
Garg DC, Baltodano N, Jallad NS, et al "Pharmacokinetics of ranitidine in patients with renal failure." J Clin Pharmacol 26 (1986): 286-91
Gladziwa U, Klotz U "Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure." Clin Pharmacokinet 27 (1994): 393-408
McGonigle RJ, Williams LC, Amphlett GE, et al "The pharmacokinetics of ranitidine in renal disease." Pharmacokinet Pharmacodynam (1982): 41-7
Dixon JS, Borgcostanzi JM, Langley SJ, Lacey LF, Toon S "The effect of renal function on the pharmacokinetics of ranitidine." Eur J Clin Pharmacol 46 (1994): 167-71
"Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
Zech PY, Chau NP, Pozet N, et al "Ranitidine kinetics in chronic renal impairment." Clin Pharmacol Ther 34 (1983): 667-72

Ranitidine

Generic Name: ranitidine

Brand Name: Zantac

Synonyms: n.a.

What is Ranitidine?