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Ranitidine and Liver disease

Result of checking the interaction of drug Ranitidine and disease Liver disease for safety when used together.

Check result:

Ranitidine <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ranitidine is partially metabolized by the liver. Although dosage reductions are generally not necessary, therapy with ranitidine should be administered cautiously in patients with liver disease. Elevated ALT (SGPT) has been observed in patients receiving ranitidine intravenously at dosages greater than those normally recommended for 5 days or more.

References:

"Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
Gonzalez-Martin G, Paulos C, Veluso B, et al "Ranitidine disposition in severe hepatic cirrhosis." Int J Clin Pharmacol Ther Toxicol 25 (1987): 139-42
Young CJ, Daneshmend TK, Roberts CJC "Effects of cirrhosis and ageing on the elimination and bioavailability of ranitidine." Gut 23 (1982): 819-23
Okolicsanyi L, Venuti M, Strazzabosco M, et al "Oral and intravenous pharmacokinetics of ranitidine in patients with liver cirrhosis." Int J Clin Pharmacol Ther Toxicol 22 (1984): 329-32
Morichau-Beauchant M, Houin G, Mavier P, et al "Pharmacokinetics and bioavailability of ranitidine in normal subjects and cirrhotic patients." Dig Dis Sci 31 (1986): 113-8
Smith IL, Ziemniak JA, Bernhard H, et al "Ranitidine disposition and systemic availability in hepatic cirrhosis." Clin Pharmacol Ther 35 (1984): 487-94

Ranitidine

Generic Name: ranitidine

Brand Name: Zantac

Synonyms: n.a.

What is Ranitidine?