Drug search by name

Quinupristin and dalfopristin Intravenous and Liver disease

Result of checking the interaction of drug Quinupristin and dalfopristin Intravenous and disease Liver disease for safety when used together.

Check result:

Quinupristin and dalfopristin Intravenous <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Quinupristin and dalfopristin are both primarily metabolized by the liver and excreted in the bile. Therapy with quinupristin-dalfopristin should be administered cautiously in patients with impaired hepatic function, since drug accumulation may occur. Dosage reduction may be necessary, although specific recommendations are not available. In clinical trials of quinupristin-dalfopristin, the incidence of adverse effects was similar in patients with chronic liver insufficiency or cirrhosis and in patients with normal hepatic function.

References:

Griswold MW, Lomaestro BM, Briceland LL "Quinupristin-dalfopristin (RP 59500): an injectable streptogramin combination." Am J Health Syst Pharm 53 (1996): 2045-53
Low DE "Quinupristin/dalfopristin: spectrum of activity, pharmacokinetics, and initial clinical experience." Microb Drug Resist 1 (1995): 223-34
"Product Information. Synercid (dalfopristin-quinupristin)" Rhone-Poulenc Rorer, Collegeville, PA.
Chant C, Rybak MJ "Quinupristin/dalfopristin (RP 59500): a new streptogramin antibiotic." Ann Pharmacother 29 (1995): 1022-7

Quinupristin and dalfopristin Intravenous

Generic Name: dalfopristin / quinupristin

Brand Name: Synercid

Synonyms: Dalfopristin and quinupristin, Quinupristin and Dalfopristin

What is Quinupristin and dalfopristin Intravenous?