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Quinine and Liver impairment

Result of checking the interaction of drug Quinine and disease Liver impairment for safety when used together.

Check result:

Quinine <> Liver impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In patients with severe hepatic impairment (Child-Pugh C), quinine oral clearance is decreased, volume of distribution is increased, and half-life is prolonged, relative to subjects with normal liver function. Therefore, quinine is not indicated in patients with severe hepatic impairment and alternate therapy should be administered. Adjustment of the recommended dose is not required in mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment, but patients should be monitored closely for adverse effects of quinine.

Quinine

Generic Name: quinine

Brand Name: Qualaquin, QM-260, Quinamm

Synonyms: QuiNINE

What is Quinine?