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Quetiapine Extended-Release Tablets and ALT elevations

Generic Name: quetiapine
Dosage Forms: n.a.
Other Brand Names: Seroquel , Seroquel XR

Result of checking the interaction of drug Quetiapine Extended-Release Tablets and disease ALT elevations for safety when used together.

Check result:

Quetiapine Extended-Release Tablets <> ALT elevations

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of quetiapine may be associated with transient, asymptomatic elevations in serum transaminase. During a series of 3- to 6-week clinical trials, 6% of patients exposed to quetiapine experienced ALT (SGPT) elevations greater than three times the upper limit of normal, compared to 1% in the placebo group. Liver enzymes tended to increase within the first 3 weeks of therapy and return to baseline with continued treatment. Therapy with quetiapine should be administered cautiously in patients with signs and symptoms of hepatic impairment. Periodic assessment of serum transaminases should be performed in patients with significant hepatic disease.

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