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Pyrazinamide and Renal dysfunction

Result of checking the interaction of drug Pyrazinamide and disease Renal dysfunction for safety when used together.

Check result:

Pyrazinamide <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The half-life of pyrazinamide may be prolonged in patients with renal impairment. In addition, the drug's metabolites, at least one of which is pharmacologically active, may accumulate. Therapy with pyrazinamide should be administered cautiously in patients with renal dysfunction. Dosage adjustments may be necessary.

References:

Stamatakis G, Montes C, Trouvin JH, et al "Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure." Clin Nephrol 30 (1988): 230-4
"Product Information. Pyrazinamide (pyrazinamide)." VersaPharm Inc, Marietta, GA.
Ellard GA "Absorption, metabolism and excretion of pyrazinamide in man." Tubercle 50 (1969): 144-58
Mandell GL, Bennett JE, Dolin R, eds.. "Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 4th ed." New York, NY: Churchill Livingston 1 (1995):

Pyrazinamide

Generic Name: pyrazinamide

Brand Name:

Synonyms: n.a.

What is Pyrazinamide?