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Pseudoephedrine and Codeine and Gastrointestinal obstruction

Result of checking the interaction of drug Pseudoephedrine and Codeine and disease Gastrointestinal obstruction for safety when used together.

Check result:

Pseudoephedrine and Codeine <> Gastrointestinal obstruction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Patients with gastrointestinal obstruction, particularly paralytic ileus, should generally not be given sustained-release oral formulations of narcotic analgesics. Opioid agents are is contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus. In such patients, the ingested drug may remain in the stomach for an extended period of time, then released suddenly as a bolus when normal gut motility is restored, thereby increasing the risk for adverse effects and/or an overdose.

References:

"Product Information. OxyContin (oxycodone)." Purdue Frederick Company, Norwalk, CT.
"Product Information. Kadian (morphine)." Zeneca Pharmaceuticals, Wilmington, DE.

Pseudoephedrine and Codeine

Generic Name: codeine / pseudoephedrine

Brand Name: Codar D, Nucofed, KG-Fed, Cycofed, Nucodine, Notuss-DC, EndaCof-DC

Synonyms: Codeine and pseudoephedrine, Pseudoephedrine and Codeine Syrup

What is Pseudoephedrine and Codeine?