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Arimidex and Hepatic dysfunction

Result of checking the interaction of drug Arimidex and disease Hepatic dysfunction for safety when used together.

Check result:

Arimidex <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Anastrozole is extensively metabolized by the liver. Analysis of the pharmacokinetic disposition of anastrozole in patients with hepatic cirrhosis indicates that dosage adjustments of anastrozole are not necessary in patients with mild to moderate hepatic impairment. Clinical monitoring for toxicity associated with anastrozole therapy is recommended. Therapy with anastrozole should be administered cautiously in patients with severe hepatic impairment.

References:

"Product Information. Arimidex (anastrozole)." Zeneca Pharmaceuticals, Wilmington, DE.
Lonning PE, Geisler J, Dowsett M "Pharmacological and clinical profile of anastrozole." Breast Cancer Res Treat 49 (1998): s53-7

Arimidex

Generic Name: anastrozole

Brand Name: Arimidex

Synonyms: n.a.

What is Arimidex?