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Prudoxin and Renal/hepatic dysfunction

Result of checking the interaction of drug Prudoxin and disease Renal/hepatic dysfunction for safety when used together.

Check result:

Prudoxin <> Renal/hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Doxepin topical is systemically absorbed and metabolized by the liver to an active form. Parent drug and metabolites are eliminated by the kidney. Renal and hepatic impairment alter the metabolism and elimination of doxepin and/or its metabolites.

References:

Faulkner RD, Senekjian HO, Lee CS "Hemodialysis of doxepin and desmethyldoxepin in uremic patients." Artif Organs 8 (1984): 151-5
Jones MI, Skaufle ML "Systemic adverse effects from topical doxepin cream." Ann Pharmacother 35 (2001): 505-6
"Product Information. Zonalon (doxepin topical)." Bioglan Pharmaceutical Inc, Malvern, PA.
Ziegler VE, Biggs JT, Wylie LT, Rosen SH, Hawf DJ, Coryell WH "Doxepin kinetics." Clin Pharmacol Ther 23 (1978): 573-9

Prudoxin

Generic Name: doxepin topical

Brand Name: Prudoxin, Zonalon

Synonyms: n.a.

What is Prudoxin?