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Propulsid (Cisapride Suspension) and Cardiac disease

Result of checking the interaction of drug Propulsid (Cisapride Suspension) and disease Cardiac disease for safety when used together.

Check result:

Propulsid (Cisapride Suspension) <> Cardiac disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of cisapride is contraindicated in patients with cardiac disease. Serious cardiac arrhythmias, including ventricular arrhythmias and torsades de pointes associated with QT prolongation have been rarely associated with the use of cisapride, especially when taken in conjunction with other medications known to prolong the QT interval.

References:

"Product Information. Propulsid (cisapride)." Janssen Pharmaceutica, Titusville, NJ.
Gunasekaran TS, DuBrow I "Cisapride-induced long QT interval: What is the role of ranitidine?" J Pediatr 130 (1997): 679-80
Bedu A, Lupoglazoff JM, Faure C, Denjoy I, Casasoprana A, Aujard Y "Cisapride high dosage and long QT interval." J Pediatr 130 (1997): 164
Bran S, Murray WA, Hirsch IB, Palmer JP "Long QT syndrome during high-dose cisapride." Arch Intern Med 155 (1995): 765-8
Hill SL, Evangelista JK, Pizzi AM, Mobassaleh M, Fulton DR, Berul CI "Proarrhythmia associated with cisapride in children." Pediatrics 101 (1998): 1053-6
Grifka R, Lewin M "Cisapride-induced long QT interval: What is the role of ranitidine? - Reply." J Pediatr 130 (1997): 680
Hanson R, Browne G, Fasher B, Mcaskill M, Moroney P, Hawker R "Cisapride-induced prolonged QT interval: too much of a good thing!." J Pediatr 130 (1997): 164-6
Lewin MB, Bryant RM, Fenrich AL, Grifka RG "Cisapride-induced long QT interval." J Pediatr 128 (1996): 279-81
Gray VS "Syncopal episodes associated with cisapride and concurrent drugs." Ann Pharmacother 32 (1998): 648-51
Bennett JR "How safe and acceptable is cisapride?" Scand J Gastroenterol Suppl 165 (1989): 59-61
Ahmad SR, Wolfe SM "Cisapride and torsades de pointes." Lancet 345 (1995): 508
Grifka RG "Cisapride high dosage and long QT interval - reply." J Pediatr 130 (1997): 164
Wysowski DK "Cisapride and fatal arrhythmia." N Engl J Med 335 (1996): 290-1
Wysowski DK, Bacsanyi J "Cisapride and fatal arrhythmia." N Engl J Med 335 (1996): 290-1
Ault A "US FDA warns doctors to use cisapride as last resort only." Lancet 352 (1998): 120