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Propranolol and Hydrochlorothiazide and Liver disease

Result of checking the interaction of drug Propranolol and Hydrochlorothiazide and disease Liver disease for safety when used together.

Check result:

Propranolol and Hydrochlorothiazide <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Propranolol is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from propranolol due to decreased drug clearance. Therapy with propranolol should be administered cautiously in patients with liver disease. Dosage adjustments may be necessary.

References:

George CF, Orme ML, Buranapong P, et al "Contribution of the liver to overall elimination of propranolol." J Pharmacokinet Biopharm 4 (1976): 17-27
Silber BM, Holford NH, Riegelman S "Dose-dependent elimination of propranolol and its major metabolites in humans." J Pharm Sci 72 (1983): 725-32
"Product Information. Inderal (propranolol)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Sotaniemi EA, Anttila M, Pelkonen RO, et al "Plasma clearance of propranolol and sotalol and hepatic drug-metabolizing enzyme activity." Clin Pharmacol Ther 26 (1979): 153-61
Jones DB "Propranolol disposition in cirrhosis ." Gut 26 (1985): 865
Routledge PA, Shand DG "Clinical pharmacokinetics of propranolol." Clin Pharmacokinet 4 (1979): 73-90
Arthur MJ, Tanner AR, Patel C, et al "Pharmacology of propranolol in patients with cirrhosis and portal hypertension." Gut 26 (1985): 14-9
Pessayre D, Lebrec D, Descatoire V, et al "Mechanism for reduced drug clearance in patients with cirrhosis." Gastroenterology 74 (1978): 566-71
Walle T, Walle K, Mathur RS, Palesch YY, Conradi EC "Propranolol metabolism in normal subjects: association with sex steroid hormones." Clin Pharmacol Ther 56 (1994): 127-32
Branch RA, Shand DG "Propranolol disposition in chronic liver disease: a physiological approach." Clin Pharmacokinet 1 (1976): 264-79
Watson RG, Bastain W, Larkin KA, et al "A comparative pharmacokinetic study of conventional propranolol and long acting preparation of propranolol in patients with cirrhosis and normal controls." Br J Clin Pharmacol 24 (1987): 527-35

Propranolol and Hydrochlorothiazide

Generic Name: hydrochlorothiazide / propranolol

Brand Name: Inderide, Inderide LA

Synonyms: Hydrochlorothiazide and propranolol

What is Propranolol and Hydrochlorothiazide?

Another drug Delete

Propranolol and Hydrochlorothiazide <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Patients with severe liver disease or cirrhosis are very susceptible to thiazide-induced hypokalemic hypochloremic alkalosis. Blood ammonia concentrations may be further increased in patients with previously elevated concentrations. Hepatic encephalopathy and death have occurred secondary to the electrolyte alterations accompanying diuretic use. Therapy with thiazide diuretics should be administered cautiously in patients with impaired hepatic function or progressive liver disease, and discontinued promptly if signs of impending hepatic coma appear (e.g., tremors, confusion, and increased jaundice).

References:

Sherlock S, Senewiratne B, Scott A, Walker JG "Complications of diuretic therapy in hepatic cirrhosis." Lancet 1 (1966): 1049-52
"Product Information. Zaroxolyn (metolazone)." Rhone-Poulenc Rorer, Collegeville, PA.
"Product Information. Metahydrin (trichlormethiazide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
"Product Information. Diucardin (hydroflumethiazide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Enduron (methyclothiazide)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Renese-R (reserpine-polythiazide)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Thalitone (chlorthalidone)." Monarch Pharmaceuticals Inc, Bristol, TN.
"Product Information. HydroDIURIL (hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Sherlock S, Walker JG, Senewiratne B, Scott A "The complications of diuretic therapy in patients with cirrhosis." Ann N Y Acad Sci 139 (1966): 497-505
"Product Information. Lozol (indapamide)." Rhone-Poulenc Rorer, Collegeville, PA.
Aneckstein AG, Weingold AB "Chlorothiazide-induced hepatic coma in pregnancy." Am J Obstet Gynecol 95 (1966): 136-7
"Product Information. Diuril (chlorothiazide)." Merck & Co, Inc, West Point, PA.