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Propofol and Cardiovascular dysfunction

Result of checking the interaction of drug Propofol and disease Cardiovascular dysfunction for safety when used together.

Check result:

Propofol <> Cardiovascular dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Propofol can induce severe hypotension and/or cardiovascular depression, particularly during the induction phase of sedation or anesthesia. Use of propofol infusions for both adult and pediatric ICU sedation has been associated with a constellation of metabolic derangements and organ system failures, referred to as Propofol Infusion Syndrome, that have resulted in death. The syndrome is characterized by severe metabolic acidosis, hyperkalemia, lipemia, rhabdomyolysis,hepatomegaly, renal failure, ECG changes (ST segment elevation similar to that in Brugada syndrome) and/or cardiac failure. Therapy with propofol should be administered cautiously in patients with preexisting cardiovascular disorders, hemodynamic impairment, increased intracranial pressure, or impaired cerebral circulation.

References:

Mackay P "Fatal cardiovascular collapse following propofol induction in high-risk patients." Anaesth Intensive Care 24 (1996): 125-6
Deutschman CS, Harris AP, Fleisher LA "Changes in heart rate variability under propofol anesthesia: a possible explanation for propofol-induced bradycardia." Anesth Analg 79 (1994): 373-7
Warden JC, Pickford DR "Fatal cardiovascular collapse following propofol induction in high-risk patients and dilemmas in the selection of a short-acting induction agent." Anaesth Intensive Care 23 (1995): 485-7
"Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.

Propofol

Generic Name: propofol

Brand Name: Diprivan, Propoven

Synonyms: n.a.

What is Propofol?