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Prochlorperazine and Anticholinergic effects

Result of checking the interaction of drug Prochlorperazine and disease Anticholinergic effects for safety when used together.

Check result:

Prochlorperazine <> Anticholinergic effects

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Phenothiazines have anticholinergic activity, to which elderly patients are particularly sensitive. Low-potency agents such as chlorpromazine and thioridazine tend to exhibit greater anticholinergic effects than other agents in the class. Therapy with phenothiazines should be administered cautiously in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders.

References:

"Product Information. Mellaril (thioridazine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Stelazine (trifluoperazine)" SmithKline Beecham, Philadelphia, PA.
"Product Information. Sparine (promazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Thorazine (chlorpromazine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Prolixin (fluphenazine)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
"Product Information. Compazine (prochlorperazine)." SmithKline Beecham, Philadelphia, PA.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM "Pharmacotherapy: A Pathophysiologic Approach 4th" Stamford, CT: Appleton & Lange (1999):
"Product Information. Vesprin (triflupromazine)" Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Trilafon (perphenazine)" Schering Corporation, Kenilworth, NJ.
"Product Information. Serentil (mesoridazine)" Boehringer-Ingelheim, Ridgefield, CT.