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Probalan and Blood dyscrasias

Result of checking the interaction of drug Probalan and disease Blood dyscrasias for safety when used together.

Check result:

Probalan <> Blood dyscrasias

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The manufacturer does not recommend the use of probenecid in patients with known blood dyscrasias. Aplastic anemia, leukopenia, hemolytic anemia and other anemia have been reported infrequently during administration of probenecid. Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may increase the risk of probenecid-induced hemolytic anemia.

References:

Gutman AB "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Adv Pharmacol 4 (1966): 91-142
Sosler SD, Behzad O, Garratty G, et al "Immune hemolytic anemia associated with probenecid." Am J Clin Pathol 84 (1985): 391-4
"Product Information. Benemid (probenecid)." Merck & Co, Inc, West Point, PA.
Kickler TS, Buck S, Ness P, et al "Probenecid induced immune hemolytic anemia." J Rheumatol 13 (1986): 208-9

Probalan

Generic Name: probenecid

Brand Name: Benemid

Synonyms: Probenecid

What is Probalan?