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Pravastatin and Renal dysfunction

Result of checking the interaction of drug Pravastatin and disease Renal dysfunction for safety when used together.

Check result:

Pravastatin <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pravastatin is partially eliminated by the kidney. Drug and/or metabolite accumulation may occur in patients with significant renal impairment, which may increase the risk of adverse effects, including hepatic and musculoskeletal toxicities. Therapy with pravastatin should be administered cautiously in patients with severely impaired renal function. A lower initial dosage may be appropriate, accompanied by close clinical monitoring.

References:

Sigurbjornsson S, Kjartansdottir T, Johannsson M, Kristinsson J, Sigurdsson G "A pharmacokinetic evaluation of pravastatin in middle-aged and elderly volunteers." Eur J Drug Metab Pharmacokinet 23 (1998): 13-8
Pan HY, Morrison RA, Singhvi SM, Frantz BM, Waclawski AP, Willard DA "Disposition of pravastatin sodium (SQ 31,000), a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects." Clin Res 36 (1988): a368
Halstenson CE, Triscari J, DeVault A, Shapiro B, Keane W, Pan H "Single-dose pharmacokinetics of pravastatin and metabolites in patients with renal impairment." J Clin Pharmacol 32 (1992): 124-32
Quion JAV, Jones PH "Clinical pharmacokinetics of pravastatin." Clin Pharmacokinet 27 (1994): 94-103
"Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb, Princeton, NJ.
Lennernas H, Fager G "Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences." Clin Pharmacokinet 32 (1997): 403-25
Pan HY, DeValut AR, Wang-Iverson D, et al "Comparative pharmacokinetics and pharmacodynamics of pravastatin and lovastatin." J Clin Pharmacol 30 (1990): 1128-35

Pravastatin

Generic Name: pravastatin

Brand Name: Pravachol

Synonyms: n.a.

What is Pravastatin?