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Pimozide and Renal/liver disease

Result of checking the interaction of drug Pimozide and disease Renal/liver disease for safety when used together.

Check result:

Pimozide <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pimozide is extensively metabolized by the liver, and both parent drug and metabolites are eliminated by the kidney. Patients with impaired renal and/or hepatic function may be at greater risk for adverse effects due to drug and metabolite accumulation. Therapy with pimozide should be administered cautiously in such patients.

References:

"Product Information. Orap Tablets (pimozide)." Gate Pharmaceuticals, Sellersville, PA.
Pinder RM, Brogden RN, Swayer R, Speight TM, Spencer R, Avery GS "Pimozide: a review of its pharmacological properties and therapeutic uses in psychiatry." Drugs 12 (1976): 1-40

Pimozide

Generic Name: pimozide

Brand Name: Orap

Synonyms: n.a.

What is Pimozide?