Drug search by name

Phenytoin Capsules and Megaloblastic anemia

Result of checking the interaction of drug Phenytoin Capsules and disease Megaloblastic anemia for safety when used together.

Check result:

Phenytoin Capsules <> Megaloblastic anemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hydantoin anticonvulsants may interfere with folate metabolism and precipitate macrocytosis and megaloblastic anemia, which usually respond to folic acid therapy. These reactions have been fairly uncommon but may be of concern in patients with megaloblastic anemia or folate deficiency receiving hydantoin therapy.

References:

"Product Information. Mesantoin (mephenytoin)" Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Peganone (ethotoin)" Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Cerebyx (fosphenytoin)." Parke-Davis, Morris Plains, NJ.
Goggin T, Gough H, Bissessar A, et al "A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy." Q J Med 65 (1987): 911-9
"Product Information. Dilantin (phenytoin)." Parke-Davis, Morris Plains, NJ.

Phenytoin Capsules

Generic Name: phenytoin

Brand Name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Capsules?