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Phentolamine Injection and Hepatic/renal dysfunction

Result of checking the interaction of drug Phentolamine Injection and disease Hepatic/renal dysfunction for safety when used together.

Check result:
Phentolamine Injection <> Hepatic/renal dysfunction
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The pharmacokinetic disposition of phentolamine has not been fully determined. Limited data suggest that phentolamine is metabolized by the liver. Phentolamine is eliminated by the kidney and approximately 13% is excreted unchanged in the urine. Therapy with phentolamine should be administered cautiously in patients with severe liver and/or renal function. Clinical monitoring of hepatic and/or renal function is recommended.

References:
  • "Product Information. Regitine (phentolamine)." Ciba Pharmaceuticals, Summit, NJ.
Phentolamine Injection

Generic Name: phentolamine

Brand Name: OraVerse

Synonyms: Phentolamine

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