Drug search by name

Perindopril and Amlodipine and Hyperkalemia

Result of checking the interaction of drug Perindopril and Amlodipine and disease Hyperkalemia for safety when used together.

Check result:

Perindopril and Amlodipine <> Hyperkalemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In patients with hyperkalemia, especially those associated with impaired renal function or congestive heart failure, ACE inhibitors may further raise serum potassium levels. Therapy with ACE inhibitors should be administered cautiously in patients with or predisposed to hyperkalemia, and serum potassium levels should be carefully monitored. Risk factors for the development of hyperkalemia during ACE inhibitor therapy include renal insufficiency, diabetes mellitus, and the concomitant use of potassium-sparing diuretics, potassium supplements, and/or potassium-containing salt substitutes.

References:

"Product Information. Mavik (trandolapril)." Knoll Pharmaceutical Company, Whippany, NJ.
Kostis JB, Shelton BJ, Yusuf S, Weiss MB, Capone RJ, Pepine CJ, Gosselin G, Delahaye F, Probstfield JL, Cahill L, Dutton D "Tolerability of enalapril initiation by patients with left ventricular dysfunction: results of the medication challenge phase of the studies of left ventricular dysfunction." Am Heart J 128 (1994): 358-64
Alderman CP "Adverse effects of the angiotensin-converting enzyme inhibitors." Ann Pharmacother 30 (1996): 55-61
"Product Information. Vasotec (enalapril)." Merck & Co, Inc, West Point, PA.
"Product Information. Accupril (quinapril)." Parke-Davis, Morris Plains, NJ.
"Product Information. Monopril (fosinopril)." Bristol-Myers Squibb, Princeton, NJ.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
"Product Information. Altace (ramipril)." Hoechst Marion-Roussel Inc, Kansas City, MO.
"Product Information. Prinivil (lisinopril)." Merck & Co, Inc, West Point, PA.
Tramonti G, Donadio C, Confessore N, Bianchi C "Antihypertensive activity and renal effects of benazepril in humans." Kidney Int (suppl 5) (1996): s107-8
Moyses C, Higgins TJ "Safety of long-term use of lisinopril for congestive heart failure." Am J Cardiol 70 (1992): c91-7
Kindler J, Schunkert H, Gassmann M, Lahn W, Irmisch R, Debusmann ER, Ocon-Pujadas J, Ritz E, Sieberth HG "Therapeutic efficacy and tolerance of ramipril in hypertensive patients with renal failure." J Cardiovasc Pharmacol 13 (1989): s55-8
"Product Information. Capoten (captopril)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Lotensin (benazepril)." Ciba Pharmaceuticals, Summit, NJ.
Antonios TFT, Macgregor GA "Angiotensin converting enzyme inhibitors in hypertension: potential problems." J Hypertens 13 Suppl (1995): s11-6
"Product Information. Aceon (perindopril)." Solvay Pharmaceuticals Inc, Marietta, GA.
"Product Information. Univasc (moexipril)." Schwarz Pharma, Mequon, WI.
Kostis JB, Shelton B, Gosselin G, Goulet C, Hood WB, Kohn RM, Kubo SH, Schron E, Weiss MB, Willis PW, Young JB, Probstfie "Adverse effects of enalapril in the studies of left ventricular dysfunction (SOLVD)." Am Heart J 131 (1996): 350-5