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Perindopril and Amlodipine and Cardiogenic shock/hypotension

Result of checking the interaction of drug Perindopril and Amlodipine and disease Cardiogenic shock/hypotension for safety when used together.

Check result:

Perindopril and Amlodipine <> Cardiogenic shock/hypotension

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In general, calcium channel blockers (CCBs) should not be used in patients with hypotension (systolic pressure < 90 mm Hg) or cardiogenic shock. Due to potential negative inotropic and peripheral vasodilating effects, the use of CCBs may further depress cardiac output and blood pressure, which can be detrimental in these patients. The use of verapamil and diltiazem is specifically contraindicated under these circumstances.

References:

"Product Information. Calan (verapamil)." Searle, Skokie, IL.
Stehle G, Buss J, Eibach J, et al "Cardiogenic shock associated with verapamil in a patient with liver cirrhosis." Lancet 336 (1990): 1079
"Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.
"Product Information. Vascor (bepridil)." McNeil Pharmaceutical, Raritan, NJ.
Kubota K, Pearce GL, Inman WHW "Vasodilation-related adverse events in diltiazem and dihydropyridine calcium antagonists studied by prescription-event monitoring." Eur J Clin Pharmacol 48 (1995): 1-7
Pahor M, Manto A, Pedone C, Carosella L, Guralnik JM, Carbonin P "Age and severe adverse drug reactions caused by nifedipine and verapamil." J Clin Epidemiol 49 (1996): 921-8

Perindopril and Amlodipine

Generic Name: amlodipine / perindopril

Brand Name: Prestalia

Synonyms: Amlodipine and perindopril

What is Perindopril and Amlodipine?